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Search Results for " cl? channels "

20

Compounds

Cat No. Product Name Synonyms Targets
T7638 NPPB Chloride channel
NPPB is a chloride channel blocker with IC50 of 80 nM .
T15192 Eact Chloride channel
Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.
T8960 MONNA Chloride channel
MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
T0275 Meticrane Fontiliz,Arresten Chloride channel , Sodium Channel
Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.
T16346 NS1652 Chloride channel
NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
T13059 T16Ainh-A01 Chloride channel
T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated chloride channel (CaCC).
T10979 DCPIB Potassium Channel , Chloride channel
DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM, demonstrating at least 100-fold higher affinity over TREK1...
T15233 Endovion NS3728 Chloride channel
Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
TN1035 Irisolidone IL Receptor , NF-κB , Chloride channel
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
T0858 Flufenamic acid Arlef,Nichisedan,Achless Potassium Channel , Calcium Channel , Chloride channel , COX , AMPK , Parasite
Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.
T2498 Adjudin AF-2364 Chloride channel , Mitochondrial Metabolism
Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
T0693 Niflumic acid Nifluril,Forenol,Landruma Others , Phospholipase , Chloride channel , COX , Monocarboxylate transporter , UGT
Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
T4330 CaCCinh-A01 Chloride channel
CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
T13536 Afoxolaner Chloride channel , GABA Receptor , Parasite
Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting i...
T4503 Talniflumate Somalgen Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o...
T6307 Lubiprostone SPI-0211,RU-0211 Chloride channel
Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
T4059 Selamectin UK-124114 Chloride channel , P-gp , Parasite
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel...
T1125 Shikonin NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid TNF , NF-κB , Chloride channel , HIV Protease , PKM
Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.
T22330 Fenamic acid 2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid Chloride channel
Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), inc...
T31597 Ecabapide DQ2511,DQ 2511,DQ-2511 Others
Ecabapide (DQ-2511) is a novel gastrointestinal motility promoter that significantly enhances gastric emptying in SHRSP.Ecabapide activates cyclic GMP-dependent housekeeping Cl- channels in rabbit gastric wall cells.

Compounds

NPPB
T7638
Synonym:
Target: Chloride channel
Eact
T15192
Synonym:
Target: Chloride channel
MONNA
T8960
Synonym:
Target: Chloride channel
Meticrane
T0275
Synonym: Fontiliz,Arresten
Target: Chloride channel, Sodium Channel
NS1652
T16346
Synonym:
Target: Chloride channel
T16Ainh-A01
T13059
Synonym:
Target: Chloride channel
DCPIB
T10979
Synonym:
Target: Potassium Channel, Chloride channel
Endovion
T15233
Synonym: NS3728
Target: Chloride channel
Irisolidone
TN1035
Synonym:
Target: IL Receptor, NF-κB, Chloride channel
Flufenamic acid
T0858
Synonym: Arlef,Nichisedan,Achless
Target: Potassium Channel, Calcium Channel, Chloride channel, COX, AMPK, Parasite
Adjudin
T2498
Synonym: AF-2364
Target: Chloride channel, Mitochondrial Metabolism
Niflumic acid
T0693
Synonym: Nifluril,Forenol,Landruma
Target: Others, Phospholipase, Chloride channel, COX, Monocarboxylate transporter, UGT
CaCCinh-A01
T4330
Synonym:
Target: Chloride channel
Afoxolaner
T13536
Synonym:
Target: Chloride channel, GABA Receptor, Parasite
Talniflumate
T4503
Synonym: Somalgen
Target: Chloride channel, COX, N-Acetylglucosaminyltransferase, Anion Exchanger
Lubiprostone
T6307
Synonym: SPI-0211,RU-0211
Target: Chloride channel
Selamectin
T4059
Synonym: UK-124114
Target: Chloride channel, P-gp, Parasite
Shikonin
T1125
Synonym: NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid
Target: TNF, NF-κB, Chloride channel, HIV Protease, PKM
Fenamic acid
T22330
Synonym: 2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid
Target: Chloride channel
Ecabapide
T31597
Synonym: DQ2511,DQ 2511,DQ-2511
Target: Others
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TargetMol